Improving ONS Compliance in Paediatrics

June 01, 2022 4 min read

Oral nutritional supplements (ONS) can be used in children who are at risk of or who have faltering growth and are often used alongside dietary changes and counselling1. ONS, however, are only effective in managing malnutrition if they are consumed as advised and there are several key factors which can impact compliance. There are also additional challenges to consider when it comes working with children including Picky Eating and Avoidant Restrictive Food Intake Disorder, both of which can benefit from appropriate use of ONS 2,3.

What can impact ONS compliance?

  • Flavour and palatability:

Sensory aspects of ONS play a major role in the perception of a product and overall opinion is considerably impacted by the taste4. Flavour perception starts to develop before we are even born, and generally younger children prefer sweeter flavours5. As children develop into teenagers, taste preferences mature and a wider range of flavours are accepted6 meaning that a variety ONS should be considered for different age ranges. Taste changes are also common during disease treatments and product acceptability may change during this time7.

  • Taste fatigue:

ONS are often prescribed in the short term, however, some children may require them for longer periods of time (e.g. those with chronic conditions such as cystic fibrosis). Taste fatigue can occur when ONS are frequently consumed over a long period of time8, highlighting the need for a variety of flavours and types of ONS when it comes to choosing appropriate products9.

  • Ready to drink versus powder ONS

Much of the compliance data available is in adult populations and are based on ready to drink formulations. Anecdotally, powdered products have also been reported to be less convenient10. A paediatric-specific study, however, found that fresh milk-based supplements were preferred in comparison to pre-prepared products11. The format of a nutritional supplement should, therefore, be considered to support its intended use and this may vary depending on the age of the child

  • Volume

Research suggests that younger children (between 1-12 years old) requiring nutrition support are more compliant with energy-dense, low-volume products in comparison with standard ONS1. This suggests that compact-style or split dose ONS may be more suitable in this age group. It is important to remember, however, that these preferences may change as children progress into their teenage years.

Top tips for improving compliance:

  1. Offer a wide variety of flavours – remember different age groups may have preferences for certain types of flavours.
  2. Offer a variety of styles of ONS. A mix-and-match approach may help combat taste fatigue and different volumes may be more appropriate for different age groups.
  3. Consider whether a ready to drink or powdered option is most suitable – this may vary depending on the situation. If a younger child requires ONS whilst at school a pre-prepared supplement may be more convenient, whereas a powdered ONS may be more suitable for an older child who is able to make the supplement up independently.
  4. Be creative with how ONS are served. Most drinks can be served chilled in a cup or a glass and some can even be frozen into ice lollies. Neutral flavoured powdered ONS can also be used to fortify everyday meals and recipes.
  5. Consider using adult ONS when appropriate. A wide range of adult ONS are suitable for use in children and these can be used to increase variety and flavour availability for those struggling with compliance. Always remember to assess micronutrient provision if considering an adult product for children.

  1. Hubbard, G et al. Energy-dense, low-volume paediatric oral nutritional supplements improve total nutrient intake and increase growth in paediatric patients requiring nutritional support: results of a randomised controlled pilot trial. European Journal of Pediatrics. 2020;179(9):1421-1430. Available from:
  2. Ghosh AK, et al. (2018). Continuation of oral nutritional supplementation supports continued growth in nutritionally at-risk children with picky eating behaviour: A post-intervention, observational follow-up study. J Int Med Res.; 46(7): 2615-2632. Available from:
  3. Gonzalez-Viana E, et al. (2017). Guideline Committee. Faltering growth in children: summary of NICE guidance. BMJ; 358: j4219. Available from:
  4. Ozcagli, T et al. A study in four European countries to examine the importance of sensory attributes of oral nutritional supplements on preference and likelihood of compliance. The Turkish Journal of Gastroenterology. 2013;24(3):266-272. Available from:
  5. Ventura, A and Worobey, J. Early Influences on the Development of Food Preferences. Current Biology. 2013;23(9):R401-R408. Available from:
  6. Nicklaus, S et al. A prospective study of food preferences in childhood. Food Quality and Preference. 2004;15(7-8):805-818. Available from:
  7. Ravasco, P. Aspects of taste and compliance in patients with cancer. European Journal of Oncology Nursing. 2005;9:S84-S91. Available from: (Aug 2021).
  8. Nieuwenhuizen, W et al. Older adults and patients in need of nutritional support: Review of current treatment options and factors influencing nutritional intake. Clinical Nutrition. 2010;29(2):160-169. Available from:
  9. Galaniha, L et al. Opportunities to improve oral nutritional supplements for managing malnutrition in cancer patients: A food design approach. Trends in Food Science & Technology. 2020;102:254-260. Available from:
  10. Johnson, A et al. Powdered oral nutritional supplements are convenient, easy to use and demonstrate excellent compliance. Clinical Nutrition ESPEN. 2020;40:639. Available from:
  11. Cohen, J et al. Paediatric oncology patient preference for oral nutritional supplements in a clinical setting. Supportive Care in Cancer. 2010;19(9):1289-1296. Available from: